Noninvasive methods to monitor dynamic single-cell events
How do cells process real-time information to survive changing environments? Traditional biochemical methods offer valuable insights, but they often rely on destructive "snapshots" that destroy the spatial and temporal context of cellular signaling.
In a new review published in Trends in Cell Biology, by Institute members Robin Lee & Jason Yeung, together with colleagues at the National Institute on Aging, UCLA, UC Santa Cruz, Novo Nordisk, and UPenn explored the cutting-edge, non-invasive toolkits transforming how we study single-cell dynamics.
By shifting static measurements to continuous, real-time observations, advanced imaging and molecular tools allow scientists to track complex signaling networks as they unfold. This dynamic perspective is crucial for uncovering how individual cells make critical decisions in health and disease.
Understanding the cell's true narrative requires watching the movie, not just looking at a single frame.
Read the full review here: https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(26)00055-3